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Background: Coronavirus in 2019 was recognized as one of the leading causes of death worldwide. According to reports, the mortality rate in people who need mechanical ventilation varies from 50 to 97 percent. The aim of this study was to evaluate the outcome of Covid-19 disease based on different characteristics in patients and mechanically ventilated variables. Method(s): This descriptive-analytical study was conducted on 160 patients with a definite diagnosis of Covid-19 who were under mechanical ventilation and admitted to the intensive care unit of Alzahra Hospital in Isfahan from March 2020 to March 2021. Data was collected by checklist. The checklist included demographic information, including age, gender, as well as information such as underlying diseases, disease outcome, length of hospitalization, etc. After collecting the data, they were analyzed in SPSS software version 22 and at a significance level of less than 0.05. Result(s): In this study, the overall mortality rate among mechanically ventilated patients was 62.5%. The mean age of patients was 69.99+/-17.87 years and the mean duration of hospitalization in surviving patients was 15.47+/-11.73 days and for deceased ones was 55.21+/-69.14 days. The mean age of the deceased group (65.71+/-16.59) was significantly higher than the surviving group 53+/-21.17 was (P=0.0001). The length of hospital stay in the deceased group was significantly longer than the surviving group (P=0.005). As a result, ventilator mode and inotropic agent intake during treatment increased the chance of mortality in patients under mechanical ventilation (P=0.001). There was a significant relationship between underlying diseases of hypertension, kidney disease and autoimmune disease with mortality in patients (P<0.05). Conclusion(s): Various factors including the length of stay in the hospital, comorbidities such as hypertension, renal disease and autoimmunity may affect the outcome of critically ill ICU patients under mechanical ventilation. Patients who require long-term invasive ventilation and the use of inotropic drugs to maintain their cardiovascular status while hospitalized in the ICU are at higher risk for mortality.Copyright © 2022 Shetabi et al. Published by Tehran University of Medical Sciences.
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Background: People with chronic diseases of the immune system, such as multiple sclerosis (MS), are at risk for Covid-19 disease. However, more research is needed with long-term follow-up. The aim of the study was to follow up people with MS (PwMS) for up to three months after AstraZeneca vaccination for the recurrence of MS and Covid-19 infection. Method(s): This study was a case study (descriptive-analytical) of follow-up type. The study population was PwMS over 18 years of age in Kermanshah province who received both doses of the AstraZeneca vaccine. This study was conducted from August to November 2021. Sampling was done with existing methods based on the National MS Registry of Iran (NMSRI). Demographic information of patients was extracted from NMSRI. A researcher-made form was used to collect information by telephone three months after vaccination about clinical characteristics, Covid-19 infection, and recurrence of MS. Data were analyzed using SPSS-25 software. Result(s): Study participants were 40 MS patients with a mean (SD) age of 39.27 (8.8) years, including 32 (80.0%) women. A mean of 9.39 (4.6) years had passed since The patients were diagnosed with MS, and 29 (76.4%) had RR type MS. Four patients (10%) relapsed between the second dose and three months later, of whom two (50%) had sensory symptoms, one (25%) had optic nerve involvement, and one (25%) had motor symptoms and pyramidal pathway involvement. The symptoms of Covid-19 were mild in three patients (10%), while severe symptoms developed in one patient (10%) who received rituximab. Among the patients, no cases of thrombosis were observed. Infusion therapy, a leg fracture, and kidney stones were the only hospitalized cases. Conclusion(s): Covid-19 and MS relapse prevalence did not differ significantly in the three months before and after vaccination. There is a need for further studies with a longer follow-up period.Copyright © 2022 Razazian et al. Published by Tehran University of Medical Sciences.
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Background and Objectives: Fear of COVID-19 is common among older adults and negatively impacts on their physical and mental health. Self-regulation is an essential factor for controlling or managing excitement and anxiety. So, this study aimed to determine the relationship between fear of COVID-19 and death anxiety with the moderator role of self-regulation among the elderly residing in Qazvin. Method(s): This descriptive and cross-sectional study was performed on 430 elderly aged 60 and over living in Qazvin in 2021. Samples were selected by cluster sampling method. The demographic checklist, Templer death anxiety scale, fear of COVID-19 questionnaire, and Self-Regulation Inventory were used for collecting the data. The data were analyzed using the Path Analyze test. Result(s): The mean age of the elder participants in the study was 66.88 +/- 6.40 years old. The results showed a significant and positive relationship between fear of COVID-19 and death anxiety (beta=0.60, P<0.001) and an inverse association between fear of COVID-19 (beta=-0.24, P=0.021) and death anxiety (beta=-0.10, P=0.021) with self-regulation. Furthermore, the results of the Path analysis confirmed the moderator role of self-regulation in the association between fear of Covid-19 and death anxiety among the elderly residing in Qazvin, Iran. Conclusion(s): Given the mediator role of self-regulation in the relationship between fear of COVID-19 and death anxiety, it is suggested to use teaching strategies to the older adults to improve self-regulation to control and mitigate the negative impacts of the fear of COVID-19 in this vulnerable population.Copyright © 2022 The Authors.
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Aim: To determine the level of knowledge towards COVID-19 among people. Material(s) and Method(s): A cross-sectional descriptive research design was used for the present study and was conducted among people attending Darbhanga Medical College, Darbhanga, Bihar, India, to assess their knowledge regarding COVID-19. A total of 461 people were recruited for this study and sample of 400 eligible people who fulfill the inclusion criteria were enrolled. Result(s): The association of socio-demographic variables of participants and their knowledge score. It shows that group (p>0.001), gender (p=0.020), education (p=0.001), marital status (p=0.001), age (p=0.020), and inhabitants (p=0.001) were significantly associated with knowledge. Majority of participants 63% having good knowledge while 33% and 1.4% having average and poor knowledge respectively regarding the corona virus pandemic. Conclusion(s): Study concluded that many people were still had average and poor knowledge on COVID-19. Higher authorities must find the ways for making people more aware on this pandemic to control its impact.Copyright © 2023, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved.
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Background: The prevalence of emerging and re-emerging diseases has made the need for basic preparations for all health care organizations more crucial. Strengthening preparedness and formulating crisis strategies will have a great impact on reducing casualties. Given the importance of preparing hospitals to deal with such an outbreak and reduce the resulting mortality, the present study was conducted to assess their readiness against Covid-19. Method(s): The present study is a quantitative and descriptive cross-sectional research conducted from October to March 2019. Data collection used the standard checklists prepared by the European Center for the Prevention and Control of Coronavirus and the Centers for Disease Control and Prevention, consisting of eight domains and 21 components. The minimum score that each hospital could get in this checklist was 143 and the maximum was 429. The sampling method in the present study was a census, and nine reference hospitals for Corona were included in the study. All hospitals' directors, managers, quality officers and crisis secretaries and others related to hospital readiness during Covid-19 were recruited by the census. Result(s): On average, the hospitals scored 391 out of 429, indicating a fairly "high readiness" in dealing with Covid-19. The highest score obtained by the hospitals was 425 and the lowest score was 349. In terms of preparation areas, the hospitals' readiness was higher than 80% in all areas. The highest readiness of hospitals was in the fifth domain, i.e. Hand hygiene, personal protective equipment and hospital waste management. The 7th domain namely, patient placement and relocation, and patient visitor access was of the lowest preparation. Conclusion(s): The hospitals were of fairly appropriate readiness to deal with Covid-19. This level of preparedness, despite being desirable, might not reflect the real capacity of hospitals to deal with this disease. Regular evaluation of the Covid referral hospitals could help make these hospitals more prepared. Also, the experiences of hospitals that were more prepared should be used to improve the condition of other hospitals.Copyright © 2022 Jaafaripooyan et al. Published by Tehran University of Medical Sciences.
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Background and purpose: Adherence to the principles of personal protection and commitment to health guidelines and principles of prevention perform important roles in controlling COVID-19 in a community. In this re3search we studied necessary measures to prevent COVID-19 in university dormitories at Mazandaran University of Medical Sciences, 2021. Material(s) and Method(s): In this descriptive-analytical study, 114 students in active dormitories during the COVID-19 pandemic participated in an online survey and their views and knowledge about COVID-19 preventive measures in the dormitories were examined. The samples were recruited using census method and data were analyzed in SPSS. Result(s): The results of the Chi-square test showed a significant relationship between adherence to preventive measures and educational level (P=0.015). Following personal hygiene was found to be significantly different according to being a local student, having underlying diseases, and the number of students at rooms (P<0.05). Findings showed that physical distancing and screening had no significant relationship with any of the variables studied (P>0.05). Conclusion(s): The study showed that among the four areas investigated, personal hygiene practices and following the principles of prevention of COVID-19 were in a good condition, while physical distancing and screening were not satisfying. Therefore, university authorities should make serious changes to improve these issues at dormitories.Copyright © 2023, Mazandaran University of Medical Sciences. All rights reserved.
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Objective: The aim of this study is to demonstrate the effects of Covid-19 pandemic to the pharmaceutical services in community pharmacies in Turkey. Material(s) and Method(s): This research is a descriptive study. In the study, a quantitative research questionnaire form prepared by the researchers was used. Questionnaires were delivered to the volunteers online. Participants were informed and participated in the study if they gave their consent with an informed consent form. Result and Discussion: It is understood that the community pharmacists in Turkey provide their pharmacy services with great devotion during the pandemic process, but they also cope with many problems. In particular, giving the masks free of charge through community pharmacies increased the workload of pharmacists and caused some disruptions in pharmacy services, in addition, the crowd of the citizens in pharmacies to buy masks increased the risk of social distancing and the possibility of transmission. Major problems faced by community pharmacists during the pandemic;Due to the high demand for personal protective equipment and hygiene materials, the increase in workload, the need for personnel, taking measures with their own means to protect against disease, not delivering drugs and products needed by the society on time, economic and / or social support, especially for the pharmacists have economic problems It is one of the important results of the study that the existence of a national emergency action plan will guide community pharmacists in combating this pandemic of unprecedented magnitudeCopyright © 2022 University of Ankara. All rights reserved.
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Background: Coronavirus Disease 2019 (COVID-19) is a pandemic cause severe acute respiratory syndrome. It is a major public health crisis threatening humanity since world war two. Aim(s): This study aimed to assess challenges and adaptation strategies of pediatric nurses in charge of caring for children with COVID-19. Methodology: A descriptive research design was used to conduct this study. Setting(s): This study was carried out at pediatric hospital affiliated to Fayoum university hospitals. A purposive sample of 100 nurses who providing care for children with COVID-19 in the previous mentioned setting. A structured interview questionnaire sheet consisted of four parts were used for data collection: Part (1): Assess characteristics of studied sample;Part (2): Assess pediatric nurses' knowledge regarding caring for children with COVID-19;Part (3): Challenges that faced pediatric nurses in caring of children with COVID-19;Part (4): Adaptation strategies used by pediatric nurses to face of COVID-19 of children. Result(s): The results showed that 55% of the studied nurses had unsatisfactory knowledge level of caring for children with COVID-19. Regarding total challenges 75% of studied nurses had psychological challenges and 65% of the studied nurses had high working pressure. Also, regard adaptation strategy 60%, 55% and 51% of the studied nurses not used cognitive and educational adaptation, psychological and emotional adaptation and physical adaptation respectively. Conclusion(s): The present study concluded that, there was highly statistically significant between total challenges of COVID-19 and total adaptation strategies among pediatric nurses in charge of caring for children with COVID-19. Recommendations: Continuous training program for pediatric nurses to improve using of the adaptation strategies of caring for children during the COVID-19.Copyright © 2023 Scientific Publishers of India. All rights reserved.
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Background: The COVID-19 pandemic continues to pose challenges for healthcare systems across the world. Many patients infected with the virus, whether mild or severe, have nutritional complications ranging from poor appetite to the need for nutrition support. Limited research has shown that nutritional status plays a significant role in disease outcomes for COVID-19 patients. Although the American Society for Parenteral and Enteral Nutrition set guidelines for the nutritional management of COVID-19 patients, to date there are few major studies investigating the association between nutritional risk and outcomes in these patients. Thus, the purpose of this study is to assess the association between nutritional status and outcomes in hospitalized patients with COVID-19 and to identify the most common feeding practices among these patients. Method(s): A descriptive research design was used. Researchers reviewed the medical records of a random sample of 300 adult patients diagnosed with COVID-19 admitted to an academic metropolitan healthcare system between March 2020 to March 2021. Nutritional status was obtained from the admission screening and assessment documentation by a clinical dietitian (RD). Patients were then stratified based on admission nutritional status as malnourished or not. Differences in hospital length of stay (LOS), ICU LOS, ventilator dependence (in hours), and mortality were compared between groups using Mann-Whitney U, independent t-test, and chi-square tests. Result(s): Malnourished patients had a longer median (IQR) length of stay compared to non-malnourished patients (8 days (3,16) vs 4 days (3,8), p = 0.001). More patients who were malnourished expired (10/43, 23.3%) compared to patients who were not malnourished (17/ 257, 6.6%) (p = 0.002). No significant differences were observed in ICU length of stay or hours on a ventilator between groups. Most patients in the study were fed orally (87.3%), while 12.7% were fed enterally, and none of the patients were fed through use of parenteral nutrition. Conclusion(s): Results suggest that malnourished patients with COVID-19 experienced several worse outcomes compared to patients with COVID-19 who were not malnourished during hospitalization. Other known factors that influence outcomes of patients with COVID-19 were not considered in this descriptive study. Subsequent analysis to account for race, obesity, and other comorbidities is needed.
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BACKGROUND: The COVID-19 pandemic greatly affected doctors' increasing workload, especially in Primary Health Care Facilities. If this is not addressed immediately, it will affect the performance or quality of a doctor's service. AIM: This research objective is to identify the role of Primary Healthcare Facility doctors' workload in moderating the impact of the COVID-19 Pandemic on their performance. METHOD(S): The explanatory-descriptive research was conducted using a quantitative approach. The research respondents were 103 general practitioners who worked at a Primary Healthcare Facility in Malang City (35.0% male and 65.0% female, the most extensive age range was 26-35 years (74.8%), with a working period of 1-5 years. 57 (55.3%) The research instrument was a questionnaire declared valid and reliable, distributed online, and analyzed using Partial Least Square. RESULT(S): The findings demonstrated that the COVID-19 pandemic significantly positively affected the performance of Primary Healthcare Facility doctors (beta = 0.455, t stat = 11.390). The pandemic also significantly impacted workload (beta = 0.283, t stat = 4.347). Workload impacted performance significantly and positively (beta = 0.224, t stat 4.157). Workload mediates the COVID-19 Pandemic influence on doctors' performance (beta = 0.063, t stat = 3.005). CONCLUSION(S): Doctors at Primary Health Care have not all experienced a decline in performance despite the increased workload due to the COVID-19 Pandemic. It forces doctors to juggle between completing their tasks, fighting against disease, and improving their performance.Copyright © 2023.
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Background: This study analyzed the causes of death in the Korean population in 2020. Method(s): Cause-of-death data for 2020 from Statistics Korea were examined based on the Korean Standard Classification of Diseases and Causes of Death, 7th revision and the International Statistical Classification of Diseases and Related Health Problems, 10th revision. Result(s): In total, 304,948 deaths occurred, reflecting an increase of 9,838 (3.3%) from 2019. The crude death rate (the number of deaths per 100,000 people) was 593.9, corresponding to an increase of 19.0 (3.3%) from 2019. The 10 leading causes of death, in descending order, were malignant neoplasms, heart diseases, pneumonia, cerebrovascular diseases, intentional self-harm, diabetes mellitus, Alzheimer disease, liver diseases, hypertensive diseases, and sepsis. Cancer accounted for 27.0% of deaths. Within the category of malignant neoplasms, the top 5 leading organs of involvement were the lung, liver, colon, stomach, and pancreas. Sepsis was included in the 10 leading causes of death for the first time. Mortality due to pneumonia decreased to 43.3 (per 100,000 people) from 45.1 in 2019. The number of deaths due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was 950, of which 54.5% were in people aged 80 or older. Conclusion(s): These changes reflect the continuing increase in deaths due to diseases of old age, including sepsis. The decrease in deaths due to pneumonia may have been due to protective measures against SARS-CoV-2. With the concomitant decrease in fertility, 2020 became the first year in which Korea's natural total population decreased.Copyright © Korean Medical Association.
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The article discusses research which analyzed the differences in stress levels between junior high school students and college students during online learning during the COVID-19 pandemic in Indonesia. It discusses body change caused by stressors, the influence of sex on an individual's stress level, the potential of stress experienced by students to cause signs and symptoms of health problems, and factors influencing stress in male and female students.
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Objective: To determine the relationship between the organizational climate among healthcare personnel and the satisfaction of users assisted by the Mobile Emergency Care Service (SAMU) in the context of COVID-19, Piura. Material(s) and Method(s): A Likert-scale survey was administered to 80 healthcare workers to assess the organizational climate and 110 SAMU users to assess their satisfaction level and whether they met the selection criteria. The survey had one section addressed to SAMU workers and another one to SAMU users. Result(s): Out of all healthcare personnel, 51.3 % were men with an average age of 32.65 +/- 6.8 % years, and there were more registered nurses (32.50 %) than doctors (31.30 %). Out of all users, 54.5 % were men with an average age of 58.78 +/- 20.97 years, 57.3 % had no comorbidities and 84.5 % used the service once. The organizational climate and its dimensions showed healthy outcomes (96.58 +/- 3.21). Most SAMU users (51.60 %) were satisfied (57/110) while 38.20 % (42/110) were moderately satisfied and 10.20 % (11/110) showed dissatisfaction. The main hypothesis concerning the relationship between the organizational climate and the satisfaction of SAMU users (p < 0.005) was confirmed. Moreover, there was a relationship between the five dimensions and the satisfaction of users. Conclusion(s): There is a relationship between the organizational climate among SAMU healthcare workers and the satisfaction of SAMU users in Piura. The organizational climate and its dimensions, compared to the instrument developed by MINSA, showed healthy outcomes. Most patients were satisfied with the care received and the most frequent comorbidities were hypertension and type 2 diabetes mellitus.Copyright © La revista. Publicado por la Universidad de San Martin de Porres, Peru.
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BACKGROUND: The present study aims to monitor how the Italian psychiatric services changed their organizations by adapting to the COVID-19 pandemic and considering the different incidence rates of the SARS-CoV-2 infection spread in the different Regions of Italy. METHOD(S): An on line "ad hoc" questionnaire was created and administered to all Italian Mental Health Departments. The questionnaire included various typologies of mental health setting such as Mental Health Service (MHS), the psychiatric therapeutic community (TC) and the psychiatric hospital ward (PH);the Region of Italy belonging to each participants is considered in accordance to the incidence of new cases per 100.000 inhabitants, as published by the Higher Institute of Health in the bulletin of 20 April 2020. Moreover, 9 questions were administered to investigate any challenges in several aspects influenced by the pandemic. RESULT(S): One hundred seventeen questionnaires were received, complete in their answers, 66 of which belonged to MHSs, 27 to TCs and 24 to PHs. The answers collected according to psychiatric settings were all statistically significant (P<0.05), except for item no.8 concerning the periodic checks of healthcare workers in the search for SARS-CoV-2 infection (p=0.432). Considering the answers received according to the incidence rate of new cases of COVID-19 per 100.000 inhabitants, as reported in the Higher Institute of Health on 20 April 2020, there was no significant statistical difference among the answers for all the items of the questionnaire, with the exception of item no.5 regarding patient care procedures (P=0.004) as at least partially - if not totally - all the psychiatric settings considered changed their procedures for patient care according to the incidence rate of the pandemic. CONCLUSION(S): The pandemic required providing greater assistance to both psychiatric patients already in treatment and to the new ones, the new accesses. On the other hand, however, the pandemic condition had strongly affected the provision of assistance mainly by reducing the provision of services, especially on the community and thus giving priority to the management of the COVID-19 pandemic.Copyright © 2021 EDIZIONI MINERVA MEDICA.
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Background: COVID-19 has changed medical practice nowadays. One of the biggest concerns has been establishing when invasive procedures such as surgery, GI endoscopy or bone marrow transplant are safe;and if it is necessary to consider screening for asymptomatic patients. Method(s): We identified asymptomatic patients that were scheduled for invasive procedures from May 2020 to April 2021 at Clinica de Marly. Patients were asked to fill a questionnaire about GI and upper respiratory symptoms and contact with possible/confirmed cases of COVID- 19 in the last 15 days. Patients taken to emergency procedures, who had symptoms or contact with probable/confirmed cases in the last 15 days were excluded. rt-PCR was performed to screen COVID-19. Result(s): A total of 1837 patients were included. 104 rt-PCRs tested positive for SARS-CoV-2, leading to a 5.66% of identified asymptomatic patients. Patients were followed-up on the 30th day after the procedure. 1733 negative patients responded to our follow-up, in which only 1 death and 2 complications were detected. 102 positive patients were followed-up and no complications or deaths were reported. Conclusion(s): We found the presence of 5.66% of asymptomatic patients with positive rt-PCR for COVID-19. Safe screening will decide if these invasive interventions can be postponed, or, if the benefit outweighs the risks.Copyright © 2022 Asociacion Colombiana de Infectologia. All rights reserved.
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Background: Since the outbreak of COVID-19, vaccination has been considered as an important measure against it. Side effects have always been an inseparable component of vaccination, which in this study, Sinopharm vaccine, its side effects and the differences of their manifestation amongst men and women have been investigated. Objective(s): This study aimed to compare the side effects of the Sinopharm vaccine among men and women working in some medical centers in Tehran, Iran. Method(s): This cross-sectional descriptive-analytical study on 890 healthcare workers of 7 medical centers in Tehran within 2 months, from late June to late August 2021. The samples were selected by the complete enumeration method, and the required data were collected using a questionnaire. Only those who received the Sinopharm vaccine at least 10 days before the study were included. Result(s): Of 890 participants, 22.96% and 77.30% were women and men, respectively, and 65.8% of women and 78.1% of men were in the age range of 20-29 years. It was revealed that 74.75% of women and 26.16% of men had at least one side effect. The incidence of at least one side effect was significantly higher in women than in men (P<0.001). It was also found that 12 side effects were significantly higher in women than in men. Most men and women had side effects within the first 24 h after vaccination. There was no significant difference in taking therapeutic measures to reduce or minimize the post-vaccination complications between men and women;however, 9.4% of men and 27.2% of women reported a decline in their ability to perform daily activities as they were unable to do their everyday tasks the day after vaccination which was significantly different between the two groups (P<0.001). Conclusion(s): The results showed that the occurrence rate of side effects after receiving the Sinopharm vaccine was significantly higher in women than in men. Moreover, women were significantly less able to perform daily routines than men.Copyright © 2022, Author(s).
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Purpose:Home noninvasive ventilation (NIV) equipment is often observed to be dirty, potentially increasing patients' risk of respiratory infection. This study aimed to describe the cleaning practices of home NIV patients. Method(s):This single-site, cross-sectional, observational study surveyed 100 patients from the respiratory failure clinic regarding cleaning instructions, cleaning habits, barriers, and motivators to cleaning. Open-ended responses were analyzed with basic content analysis and closed categorical responses with frequencies and percentages. Result(s):Of 100 participants, 77% responded. Cleaning instructions most commonly recalled included cleaning with soapy water for masks (26/47, 55%), head straps (19/47, 40%), and tubing (21/47, 45%);vinegar solution for humidifiers (9/39, 23%);and replacing filters (14/39, 36%). Fourteen respondents reported barriers to cleaning, including forgetfulness (7/14, 50%) and physical difficulties (6/14, 43%). Commonly reported cleaning practices included soapy water to soak masks (28/77, 36%) and tubing (35/77, 46%), weekly masks (34/77, 44%) and tubing cleaning (29/77, 38%), vinegar solution to clean humidifiers for the 36 humidifier users (15/36, 44%), monthly humidifier cleaning (13/36, 36%), and monthly filter cleaning/replacement (36/77, 47%). Conclusion(s):Few respondents could recall specific instructions about when and how to clean their equipment. Many reported routine cleaning, with varied methods and frequencies. Our results will inform future NIV equipment cleaning educational package design.Copyright © Cardiovascular and Pulmonary Section, APTA.
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The COVID-19 pandemic has left millions of children and adolescents grieving the sudden death of a grandparent. Yet, we lack knowledge of the mental health implications of a grandparent's death for youth. This study uses longitudinal data to examine if the loss of a grandparent increases adolescent grandchildren's likelihood of experiencing their mothers' major depressive disorder, and of having depressive symptoms themselves. Using data from the Fragile Families and Child Wellbeing Study, a population-based cohort study of children born in 20 U.S. cities between 1998 and 2000, we estimate associations between the death of a maternal grandparent in mid-childhood and adolescents', and their mothers', depressive outcomes when the adolescent is roughly age 15 (in 2014-17), net of a robust set of covariates, including pre-bereavement depression. Adjusted regression models show no elevated depression risk associated with a grandfather's death-neither for adolescents nor their mothers. A grandmother's death within the previous seven years is associated with a higher likelihood of adolescents having a depressed mother compared to both non-bereaved adolescents (odds ratio (OR) = 2.42;95% confidence interval (CI) = 1.17, 5.01) and those whose grandmother died more than seven years ago (OR = 3.78;95% CI = 1.54, 9.31). Furthermore, adolescent boys have a 50% increase in their depressive symptoms following a grandmother's death relative to their non-bereaved peers-an increase that operates independently from the influence of the death on their mother. Together, the results show the death of a grandmother is an underappreciated, persistent risk factor for adolescents experiencing maternal major depressive disorder, and for adolescent boys experiencing depressive symptoms personally.Copyright © 2022 The Authors
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Objective: To systematically evaluate the efficacy and safety of arbidol in the treatment of novel coronavirus pneumonia (COVID-19). Method(s): Randomized controlled trials (RCTs), cohort studies, and case-control studies on the efficacy and safety of arbidol for COVID-19, influenza, andother respiratory virus infections were collected by searching related database at home and abroad and network platform for preprint of Health Science Papers (medRxiv) (up to April 25, 2020). Quality of the enrolled studies was evaluated by bias risk assessment tool of Cochrane collaboration network and Newcastle-Ottawa Scale (NOS). Meta-analysis and descriptive analysis of relevant outcome indicators were performed using RevMan 5.3 software. Result(s): A total of 15 studies were enrolled in the study, including 7 cohort studies with high-quality and 8 RCTs, 6 of which were with low bias risk and the other 2 of which were with medium bias risk. Among these studies, 8 were on arbidol treatment for COVID-19, including 5 retrospective cohort studies, 2 prospective cohort studies, and 1 RCT, and involving 809 patients (479 patients in the arbidol group and 330 in the control group);7 were RCTs on arbidol treatment for influenza or other respiratory virus infections, involving 1 471 patients (745 patients in the arbidol group and 726 in the control group).In these studies, patients were treated with arbidol (0.15-1.2 g daily for 5-21 d) in the arbidol group while with the other antiviral agents or without any antiviral drug in the control group. Meta analysis on the efficacy and safety of arbidol in treatment for COVID-19 showed that the novel coronavirus (2019-nCoV) nucleic acid negative conversion rate in the arbidol group was significantly higher than that in the control group [71.7% (109/152) vs. 58.8% (94/160), relative risk (RR)=1.30, 95% confidence interval (CI): 1.01-1.67, P=0.04];the difference of time taken for 2019-nCoV nucleic acid negative conversion between the 2 groups was not statistically significant (standardized mean difference=-0.17, 95%CI: -0.72-0.38, P=0.55);the difference of disease improvement rate shown by chest CT on day 7 after treatment between the 2 groups was not statistically significant [46.2% (30/65) vs. 50.7% (36/71), RR=0.88, 95%CI: 0.39-1.98, P=0.76];and the difference of incidence of adverse reactions between the 2 groups was not statistically significant [16.9% (39/231) vs. 19.2% (47/245), risk difference (RD)=-0.03, 95%CI: -0.10-0.04, P=0.44]. Meta analysis on the safety of arbidol in treatment for influenza and other respiratory virus infections showed that the incidence of adverse reactions in the arbidol group was significantly lower than that in the control group [5.9% (44/745) vs. 11.3% (82/726), RR=0.52, 95%CI: 0.37-0.74, P<0.01]. Conclusion(s): Arbidol could effectively increase the 2019-nCoV nucleic acid negative conversion rate and it might be safe to treat COVID-19 using arbidol.Copyright © 2020 by the Chinese Medical Association.
ABSTRACT
Objective: This research was carried out as a descriptive and cross-sectional study between January and April 2021 in order to determine the relationship between COVID-19 fear and COVID-19 hygiene behaviors in adults. Materials and Methods: The sample of the research consisted of 1876 individuals who accepted to participate in the online survey with the snowball sampling method and completed the research completely. Research data were obtained with an introductory questionnaire, COVID-19 Fear Scale and COVID-19 Hygiene Behavior Scale. In the analysis of the data, number-percentage calculations, mean, standard deviation, independent t test and ANOVA, Pearson Correlation and Linear regression tests were used. Results: The mean score of the individuals on the COVID-19 Fear Scale was found to be 19.51±.89 and the total mean score of the COVID-19 Hygiene Behaviors Scale was found to be 105.35±18.61. The COVID-19 fear level of the participants;It was determined that gender, education status, working status, place of residence, socio-economic status, individual with chronic disease at home, anxiety due to COVID-19, change in hygiene behavior, thinking that hygiene will prevent COVID-19 explained 21.4%. Variables of age, gender, education status, employment status, marital status, family type, presence of children, place of residence, socioeconomic status, individuals with chronic diseases at home, anxiety due to corona, change in hygiene behavior, thinking that hygiene will prevent corona, COVID-19 Hygiene The level of their behavior;It was determined that 14% explained. Conclusion: As the COVID-19 fear levels of individuals increase, the COVID-19 hygiene behaviors also increas. Amaç: Bu araştırma, yetişkinlerde COVID-19 korkusu ile COVID-19 hijyen davranışları arasındaki ilişkiyi belirlemek amacıyla Ocak-Nisan 2021 tarihleri arasında tanımlayıcı ve kesitsel olarak yapılmıştır. Gereç ve Yöntem: Araştırma verileri, "Veri Toplama Formu”, "COVID-19 Korkusu Ölçeği” ve "COVID-19 Hijyen Davranış Ölçeği” ile elde edilmiştir. Verilerin çözümlenmesinde sayı-yüzde hesaplamaları, ortalama, standart sapma, bağımsız t testi ve ANOVA, Pearson Korelasyon ve Lineer regresyon testleri kullanılmıştır. Bulgular: Bireylerin COVID-19 Korku Ölçeği puan ortalaması 19.51±6.89, COVID19 Hijyen Davranışları Ölçeği toplam puan ortalaması 105.35±18.61 olarak bulundu. Katılımcıların COVID-19 korku düzeyinin;cinsiyet, öğrenim durumu, çalışma durumu, yaşadığı yer, sosyoekonomik durum, evde kronik hastalığı olan birey, COVID-19 nedeniyle endişe, hijyen davranışı değişikliği, hijyenin COVID-19'u engelleyeceğini düşünme değişkenlerinin %21.4'ünü açıkladığı saptanmıştır. Yaş, cinsiyet, öğrenim durumu, çalışma durumu, medeni durum, aile tipi, çocuk varlığı, yaşadığı yer, sosyoekonomik durum, evde kronik hastalığı olan birey, korona nedeniyle endişe, hijyen davranışı değişikliği, hijyenin koronayı engelleyeceğini düşünme değişkenlerinin, COVID-19 Hijyen Davranışları düzeyinin;%14'ünü açıkladığı belirlenmiştir. Sonuç: Bireylerin COVID-19 korku düzeyleri arttıkça, COVID-19 hijyen davranışları da artmaktadır.